Here are several credible studies on inositol at menopause and its effects, especially in postmenopausal women you can look up yourself:
Giordano et al. (2011, Menopause)
This randomized, placebo-controlled trial involved 80 postmenopausal women with metabolic syndrome. Those taking 2 g myo‑inositol twice daily plus diet for 6 months showed a 75% reduction in insulin resistance (HOMA‑IR), decreased triglycerides (~20%), improved HDL, and an 11% drop in diastolic blood pressure—outperforming the diet‑only group .
Santamaria et al. (2012, Climacteric)
A follow-up to the Giordano study showed sustained improvements at 12 months in BMI, waist circumference, glucose, lipids, and blood pressure .
Mainini et al. (2024, Medicina)
In a 200-woman retrospective study, a supplement (2 g myo‑inositol + cocoa polyphenols + soy isoflavones) taken for 6 months significantly reduced hot flush frequency, lessened depression symptoms, and improved BMI, waist circumference, and glucose control .
Capasso et al. (2013, Trials)
In the randomized INOSIDEX trial, combining inositol & alpha-lipoic acid for 6 months in 155 postmenopausal women with metabolic syndrome led to >20% reductions in HOMA‑IR and triglycerides and increased HDL compared to placebo .
Let's talk for me personally...it's helped my sleep get deeper. It's helped me to be calmer. It's helped with rumination and over-thinking. It's helped my mood in general.
Let me put one more thought about inositol in your head…personally, despite not having research to show this, I believe this can be a useful part of your supplement stack to help indirectly with weight management. Naturally, if all this stress, anxiety and rumination is managed better at menopause, cortisol would also be regulated which in turn, can be a root problem of weight gain for many women.
Something to think about my beauties.
If you are on any mood altering or stabilizing medications speak with your doctor as this affects seratonin and GABA.
Why isn't inositol often spoken about for menopause?
Unsexy (no big profits)
Subtle (not a silver bullet)
Misplaced (pigeonholed as a PCOS tool)
Unknown (barely taught in med school)
Inositol treats root causes, but many providers are unaware of the research.
Most doctors learn almost nothing about:
Inositol, or other nutraceuticals even with strong evidence.
If this resonates with you, feel free to share. More insights & original conversations are on my podcast at sandykruse.ca & right here.
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